Our software automates bone age analysis (BAA) for a child. 

How to use:

1. Upload Full-Hand X-ray Image of the patient.

2. Select the sex of the child (male/female).

3. Click “generate”.

4. The full-hand age, age of individual segments of the hand (Short Bones, carpal and wrist) and the Segmental Greulich-Pyle age of the child will be displayed in the webpage.

About digiBONE

digiBONE is an AI application that automates bone age assessment of a child. It employs the widely used Greulich Pyle method of bone age assessment. Traditionally, GP assessment requires expert clinicians to compare a child’s hand X-ray with reference radiographs to determine bone age—an essential step in diagnosing growth and endocrinological disorders.

However, literature suggests that different groups of bones in the hand matures at different rates due to different hormonal influences. For instance, sex hormones govern the maturation of tubular bones (metacarpal, phalanges, radius, ulna) but the carpal maturation follows a different pattern.This implies that a single GP age for the entire hand may not be sufficient.

How digiBONE elevates bone age assessment

• Provides GP bone age for the full hand, as well as segmented assessments for short bones, carpals, and wrist.

• Introduces Segmental Greulich-Pyle bone age, accounting for variations in bone maturity across different hand regions.

Enhances diagnostic accuracy with automated, consistent and rapid assessment of bone age catering to the Indian population.

References

1. Rashmi Chapke, Shruti Mondkar, Chirantap Oza, Vaman Khadilkar, Tim R. J. Aeppli, Lars S¨avendahl, Neha Kajale, Dipali Ladkat, Anuradha Khadilkar, and Pranay Goel. The automated Greulich and Pyle: a coming-of-age for segmental methods? Frontiers in Artificial Intelligence, 7, 2024. https://www.frontiersin.org/journals/artificial-intelligence/articles/10.3389/frai.2024.1326488

2. Chirantap Oza, Anuradha V. Khadilkar, Pranay Goel, Tim Aeppli, Shruti Mondkar, Nikhil Shah, Nikhil Lohiya, Hemchand Krishna Prasad, Prashant Patil, Chidvilas More, Neha Kajale, Vaman Khadilkar, and Lars S¨avendahl. Standardization of Weightage Assigned to Different Segments of the Hand X-ray for Assessment of Bone Age by the Greulich–Pyle Method. Indian Journal of Endocrinology and Metabolism, 28(2):160–166, March 2024. https://journals.lww.com/10.4103/ijem.ijem_237_23

3. Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, and Vaman Khadilkar. Utility of BoneXpert in assessing bone age and bone health in Indian children and youth with type 1 diabetes mellitus. Bone, 178:116952, January 2024. https://linkinghub.elsevier.com/retrieve/pii/S8756328223002855

4. Chirantap Oza, Misha Antani, Shruti A. Mondkar, Neha Kajale, Vikas Ojha, Pranay Goel, Vaman Khadilkar, and Anuradha V. Khadilkar. BoneXpert-derived bone health index reference curves constructed on healthy Indian children and adolescents. Pediatric Radiology, 54(1):127–135, December 2023. https://link.springer.com/10.1007/s00247-023-05824-1

5. Chirantap Oza, Misha Antani, Shruti Mondkar, Shital Bhor, Neha Kajale, Shilpa Kajale, Pranay Goel, Vaman Khadilkar, and Anuradha Khadilkar. Adaptation and validation of an artificial intelligence based digital radiogrammetry tool for assessing bone health of indian children and youth with type-1 diabetes. Endocrine, 84(1):119–127, December 2023. https://link.springer.com/10.1007/s12020-023-03630-1

6. Rashmi Chapke. Segmentation of Pediatric Hand Radiograph Using UNet for Bone Aging. Master’s thesis, Indian Institute of Science Education and Research, May 2023. http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7873

7. Chirantap Oza, Anuradha V. Khadilkar, Shruti Mondkar, Ketan Gondhalekar, Arnav Ladkat, Nikhil Shah, Nikhil Lohiya, Hemchand Krishna Prasad, Prashant Patil, Madhura Karguppikar, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Pranay Goel, and Vaman Khadilkar. A comparison of bone age assessments using automated and manual methods in children of Indian ethnicity. Pediatric Radiology, 52(11):2188–2196, October 2022. https://link.springer.com/10.1007/s00247-022-05516-2

8. William Walter Greulich and Sarah Idell Pyle, editors. Radiographic atlas of skeletal development of the hand and wrist. Stanford Univ. Press [u.a.], Stanford, Calif, 2. ed., repr edition, 2011.